Wnt Signaling: Ig-Norrin the Dogma
نویسنده
چکیده
Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.
منابع مشابه
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ورودعنوان ژورنال:
- Current Biology
دوره 14 شماره
صفحات -
تاریخ انتشار 2004